Fig. 3: HPP decadal impact.

a The top 15 neXtProt protein descriptor groups/families with the highest number of 2020 PE2,3,4 missing protein members (i.e., lacking high-stringency PE1 evidence of protein existence data; magenta, left) and the top 15 protein descriptor groups that have been upgraded to PE1 since 2011 (green, right). The data illustrates that the OR family has the highest number of 2020 missing PE2,3,4 proteins (magenta bars) and the Zn finger protein family has the highest number of discovered PE2,3,4 entries upgraded to PE1 since 2011 b Human chromosomal distribution of the OR and Zn finger families neXtProt protein descriptor groups/families. This example data clearly illustrates that the positioning of multiple ORs (magenta vertical bars) or Zn finger protein-coding genes (green vertical bars) on certain chromsomes explains why Chr 11 appears more resistant and Chr 19 more susceptible to PE1 discovery over the decade.