Fig. 2: PSGL-1 specifically binds to P-selectin. | Nature Communications

Fig. 2: PSGL-1 specifically binds to P-selectin.

From: Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Fig. 2

a Illustrations of non-targeted and P-selectin glycoprotein ligand-1 (PSGL-1)-targeted liposomes. b Cryogenic transmission electron microscopy images of non-targeted and PSGL-1-targeted liposomes. c The binding rate of PSGL-1 to P-selectin assessed using BIAcore. d Liposomal binding of PSGL-1-targeted and non-targeted particles to ECs in vitro (all p values shown are < 0.001; n = 3 samples examined over one independent experiment). e Liposomal binding of PSGL-1-targeted and non-targeted particles to ECs in vivo (p value < 0.001; n = 4 samples examined over one independent experiment). Experiments seen here were repeated three times independently. All data presented here are defined as mean values +/− SD. Statistical significance was analyzed using an unpaired Student’s two-sided t-test (*p < 0.05).

Back to article page