Fig. 2: Gpx4 depletion promotes Kras-driven pancreatic tumorigenesis. | Nature Communications

Fig. 2: Gpx4 depletion promotes Kras-driven pancreatic tumorigenesis.

From: Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Fig. 2

a Survival of Pdx1-Cre;K-RasG12D/+ (KC) and Pdx1-Cre;K-RasG12D/+;Gpx4−/− (KCG) mice with or without liproxstatin-1 (Lip1) treatment (n = 10 mice/group; one-sided log-rank [Mantel–Cox] test). b Pancreatic weight of the indicated KC and KCG mice (6 months; n = 5 mice/group; two-way ANOVA with Tukey’s multiple comparisons test). c Representative pancreas histology of the indicated KC and KCG mice. d Percentages of histological structures in the pancreas of the indicated KC and KCG mice (6 months; n = 5 mice/group; two-way ANOVA with Tukey’s multiple comparisons test). e, f Relative gene or protein expression in the pancreas of the indicated KC and KCG mice (n = 3 mice/group; two-way ANOVA with Tukey’s multiple comparisons test). g Percentages of histological structures in the pancreas of the indicated KC and KCG+/− mice (6 months; n = 5 mice/group; two-way ANOVA with Tukey’s multiple comparisons test). h Percentages of histological structures in the pancreas of the indicated KCG mice with or without high-iron diets (3 months; n = 5 mice/group; two-way ANOVA with Tukey’s multiple comparisons test). Data in b, d, e, g, and h) are presented as mean ± SD. Data are from two or three independent experiments.

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