Fig. 4: Prevalence and genotype breakdown of ciprofloxacin and azithromycin resistant S. sonnei in three surveillance regions (Australia, England and USA) from 2016 to 2019.

In each plot, black lines indicate the proportion of genomes that are predicted resistant to (a) ciprofloxacin (defined as presence of ≥3 QRDR mutations) or (b) azithromycin (defined as carrying mph(A)). Error bars indicate 95% confidence intervals for the proportion resistant (n = 144–182 for Australia, n = 610–869 for England, n = 87–313 for USA). Stacked bars indicate the relative abundance of each genotype among resistant isolates, coloured by genotype as per legend.