Fig. 7: Clinical utility of cellular signal analysis.

A Sensitivity/Specificity of signals in classifying tumor types: Curves showing the sensitivity and specificity of using the scores defined by the color scheme to classify tumors by type at different cut-offs. The different score and tumor type pairs are: fetal interstitial cells and CMN (light blue), intercalated cells and ChRCCs (dark blue), developing nephron and Nephroblastoma (light green), PT1 and ccRCCs/pRCCs (dark green), and mature vascular and ccRCCs (red). B Median reference contribution by tumor type: Each point represents the median score for the group of samples indicated by the combination of shape (tissue type, see legend) and shading (score type, as in A). C Histology image of unclassified childhood renal tumor: The tumor mostly compromised pleomorphic epithelioid cells that formed tubules, papillae, glands and nests, as well as more solid areas with spindled cells and clefting similar to that of synovial sarcoma. Patchy tumor necrosis was apparent. Some areas showed smaller, more uniform cells lining narrow tubular structures, resembling adenomatous perilobar nephrogenic rests. Overall, the morphology and ancillary tests were inconclusive. Scale bars at bottom of each image indicate approximately 100 μm. D Immaturity score for unclassified childhood renal tumor: Calculated as in Fig. 2, with score range for normal post-natal kidney indicated on left. E Summary of signal contribution from fetal and mature kidney to unclassified childhood renal tumor: Each color represents the signal type labeled and fraction of squares of each type matches the signal contribution. F Immaturity score for childhood renal cell carcinoma: As in D. G Summary of signal contribution from fetal and mature kidney to childhood renal cell carcinoma: As in E but for a transcriptome derived from renal cell carcinoma fit using a mature kidney signal set. Source data are available as a Source Data file.