Fig. 5: A working model for Ca2+ activation of PKD1L3-CTD/2L1. | Nature Communications

Fig. 5: A working model for Ca2+ activation of PKD1L3-CTD/2L1.

From: Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel

Fig. 5

a An overall schematic illustration of the conformational changes of the heterochannel upon Ca2+ binding to the SF and VSDIII. The Ca2+ and Na+ ions are shown as red and orange circles, respectively. b A more detailed illustration of the change of channel segments corresponding to the two states shown above. Two diagonal views are shown.

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