Fig. 6: ADARs-mediated circRNA regulation exists in multiple cancer types.
From: ADARs act as potent regulators of circular transcriptome in cancer
a–d Fold change in expression of 5 validated ARcircs upon overexpression of WT, EAA, or DeAD form of ADAR1 or ADAR2, compared to the EV control, in MB231 a, MKN28 b, SNU398 c, and HCT15 d. Each dot represents the mean value of technical triplicates. Data are presented as the mean ± S.D. of 3 biological replicates. Statistical significance was calculated by paired, two-tailed Student’s t-test; *, P < 0.05; **, P < 0.01; ***, P < 0.001. e, f Fold change in expression levels of circCHEK2 (upper panels) and ADAR1 (lower panels) between 17 primary HCC tumors e and 20 primary CRC tumors f and their matched NT liver and colon samples. Upper panels, cases demonstrating ≥2 fold higher or lower circCHEK2 expression than their matched NT samples are shown by blue or red bars, respectively. Lower panels, patients were stratified into 2 groups: ‘ADAR1-up’ and ‘ADAR1-down’, according to the pattern of change in ADAR1 expression between HCC or CRC and their matched NT samples. Each dot represents the mean value of technical triplicates. Data are presented as the mean ± S.D. of 2 independent experiments. Exact P values and source data are provided in Source Data file.
