Fig. 4: The mechanism of transcriptional repression of rice PHR2 by the InsP6-bound SPX2 binding. | Nature Communications

Fig. 4: The mechanism of transcriptional repression of rice PHR2 by the InsP6-bound SPX2 binding.

From: Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 – PHR2 complex

Fig. 4

a The structure of PHR2 MYB ___domain in complex with DNA. The P1BS motif is highlighted in gray shading. b The interface between the MYB ___domain and P1BS motif. c Structure superposition of MYB/DNA complex and SPX2/InsP6/PHR2 complex. They are aligned by superposing the MYB protomer A or B of MYB/DNA structure with the MYB ___domain of PHR2 protomer A or B in the SPX2/InsP6/PHR2 complex, respectively. The two MYB molecules and DNA in the MYB/DNA complex are colored in yellow cartoon, green cartoon and gray surface representation, respectively. Steric clashes of PHR2 preventing DNA binding are illustrated in the middle model. d Structural basis for InsP6-bound SPX2 disassembles the dimerization of PHR2 CC ___domain. Residues responsible for SPX2 binding and CC dimerization are highlighted in magenta and blue, respectively. No-interacting residues are colored in black. e A model illustration for the transcription inhibition of PHR2 by InsP6/PP-InsPs.

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