Fig. 5: Network map of the multi-omics signatures of the childhood exposome.

Network visualization of the childhood Exposome-omics-Wide Association Study (ExWAS). Nodes of the network are depicted with a different colour/shape depending if they are exposures or features of a particular molecular layer (see legend in the figure). An exposure and a molecular feature were connected with an edge if their association was statistically significant (blue if positively and red if negatively). Only connected components with at least two molecular features were displayed. An exposure and a molecular feature were connected if their association was statistically significant, and only connected components with at least two molecular features were displayed. The childhood exposome network was diverse in terms of omics features represented and the level of interconnection, with the biggest connected component containing 90% of all nodes. Within this network, 11 clusters were identified using an unsupervised structural cluster analysis (see Supplementary Information), and were annotated in the figure. The summary table with the cluster characteristics are in Table 1 and the full table with the node attributes can be found in Supplementary Data 5B.