Fig. 4: Correlation between DNA methylation and nucleosome accessibility.
From: DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation
a, b Size distributions of Tn5-digested DNA during hematopoiesis in (a) Corces et al. and (b) Viny et al. datasets. c Size distribution of Tn5-digested DNA in bone marrow plasma cells in Barwick et al. Dnmt3-deficient mice model. d–f Size distributions of Tn5-digested DNA in (d) Barnett et al., (e) Izzo et al., and (f) Lhoumaud et al.. In (a) and (b), data from one single donor with fruitful cell types available were shown here; in (d–f), Tn5-digested DNA was divided into two groups (i.e., hyper- and hypo-methylated) based on the DNA methylation level. HSC hematopoietic stem cell, MPC multipotent progenitor cell, CMP common myeloid progenitor, LMPP lymphoid-primed multipotent progenitor cell, GMP granulocyte-macrophage progenitor, MEP megakaryocyte erythroid progenitor.
