Fig. 5: C1QC + and SPP1 + TAMs comprise two distinct subpopulations within the myeloid cell compartment. | Nature Communications

Fig. 5: C1QC + and SPP1 + TAMs comprise two distinct subpopulations within the myeloid cell compartment.

From: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Fig. 5

A UMAP overview of the myeloid compartment. DC dendritic cell, MDSC myeloid-derived suppressor cell, UMAP uniform manifold approximation and projection. B For each myeloid cluster, the two genes most differentially expressed between that cluster and the rest of the myeloid compartment. TAM, tumor-associated macrophages. C M1 (left) and M2 (right) polarization signatures in the macrophage populations. D Selected gene set enrichment analysis results from a comparison between SPP1 + and C1QC + TAMs. EMT, epithelial-mesenchymal transition. E Phagocytosis and angiogenesis scores for SPP1 + and C1QC + TAMs. One sample with fewer than 40 total TAM cells was excluded. (n = 26 samples; two-sided Wilcoxon rank-sum test; box plots centered around the median with hinges at 1st and 3rd quartiles and whiskers from hinge to max value or 1.5*IQR, whichever is smallest).

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