Fig. 3: An epigenetic regulatory network of chromodomain proteins.

a Hierarchical clustering of chromodomain proteins and epigenetic regulators based on the pairwise Pearson correlations of signals of ChIP-seq peaks (see Methods for details). (Red) Positive correlations; (blue) negative correlations. The development stage of animals for each sample is noted as E (embryos), L (larval), and A (adult). Sample names are labeled by different colors. Chromodomain protein samples generated in this work (green), chromodomain protein samples downloaded (red), histone modifications, and epigenetic regulators (black). b A colocalization network across the genome of chromodomain proteins and epigenetic factors. In the network, nodes indicate individual chromodomain proteins (purple), histone modifications (light pink) and other epigenetic regulators (dark pink); subnetworks identified are indicated by shadows in different colors; edge colors depict the percentages of overlap between the nodes and weight the colocalization specificity between two factors (see Methods for details). The development stage of animals for each sample is noted as E (embryos), L (larval), and A (adult).