Fig. 4: Overall functional T cell response of lung and blood compartments. | Nature Communications

Fig. 4: Overall functional T cell response of lung and blood compartments.

From: Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Fig. 4

a, b Donut charts displaying the net contribution of each functional marker (IFNγ, CD107a, IL-4, and IL-10) to the overall S-specific CD4+ (a) and CD8+ (b) T cell response within the lung resident and non-resident T cell subsets and in peripheral blood for each of the individual patient groups. Data represent the mean value of the net frequency of each function within the patient group, including both responders and non-responders. The frequency shown inside each donut chart represents the accumulated mean response of all functions for each group (Ctrl, control, n = 5; Inf, convalescent infected, n = 8; LT, vaccine 2/3 doses, n = 10, and ST, vaccine 3/4 doses, n = 5). Bar charts on the right show the mean of the total frequency considering all functions per group (mean ± SD). Statistical significance was determined by Kruskal–Wallis test (with Dunn´s post-test, two-sided) for the difference between each group. *P < 0.05. Source data are provided as a Source Data file.

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