Fig. 5: In vivo imaging in mouse models of nephritis based on the proposed Trojan horse strategy. | Nature Communications

Fig. 5: In vivo imaging in mouse models of nephritis based on the proposed Trojan horse strategy.

From: In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter

Fig. 5

a Bioluminescence imaging of S. aureus (~1.0 × 108 CFU)-induced nephritis in mice with different treatments as indicated. The infected mice were injected with GP-Si-BPs + PBS, GP-Si-BPs + Si-Luc, GP-Si-BPs + GP-Si-Luc, Si-BPs, GP-Si-Luc and Si-BPs + Si-Luc at the same dose respectively (mean ± SD, n = 3). b Bioluminescence imaging of S. aureus (~1.0 × 106 CFU)-induced nephritis in mice with different treatments as indicated. The infected mice were injected with GP-Si-BPs + PBS, GP-Si-BPs + Si-Luc, GP-Si-BPs + GP-Si-Luc, Si-BPs, GP-Si-Luc and Si-BPs + Si-Luc at the same dose, respectively (mean ± SD, n = 3). c Bioluminescence imaging of health mice (control), glycerin nephritis-bearing mice and S. aureus nephritis-bearing mice by using the Trojan BLI probes (mean ± SD, n = 3). d Luminescence imaging of health mice (control), glycerin nephritis-bearing mice and S. aureus nephritis-bearing mice by intraperitoneal administration of luminol (282 mM, 200 μL) (mean ± SD, n = 3). All imaging experiments were repeated three times with similar results. Statistical analysis was performed using a one-way ANOVA analysis. Error bars represent the standard deviation obtained from three independent measurements. Source data are provided as a Source data file.

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