Fig. 8: Adenovirus-mediated hepatic Laptm5 over-expression alleviated non-alcoholic steatohepatitis. | Nature Communications

Fig. 8: Adenovirus-mediated hepatic Laptm5 over-expression alleviated non-alcoholic steatohepatitis.

From: Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice

Fig. 8

a Scheme of constructing AdLAPTM5-mediated therapeutic NASH models in HFHC mice. b Represents the WB detection results of the proteins indicated in the groups (n = 3 mice/group). c and d Fasting blood glucose (c), liver weight, and LW/BW (d) of mice in the indicated groups (n = 10 mice/group). e Hepatic TG and TC contents of mice in the indicated group (n = 10 mice/group). f H&E (upper) (n = 6 mice/group) and Oil Red O (lower) (n = 5 mice/group) staining in the liver sections. Scale bar, 100 μm. g NAS score analysis of the group in panel (f) (n = 6 mice/group). h Statistical analysis of Oil red O in the group of the panel (f) (n = 5 mice/group). i Relative mRNA levels of genes related to the fatty acid metabolism in the livers of mice in the indicated groups (n = 6 mice/group). j and k Immunofluorescence staining (j) and Statistical analysis (k) of CD11b (red) in the liver sections of HFHC-fed mice in the indicated groups (n = 5 mice/group). Scale bar, 50 μm. l Relative mRNA levels of pro-inflammatory genes in the livers of mice in the indicated groups (n = 6 mice/group). m Serum ALT and AST concentrations of mice in the indicated groups (n = 10 mice/group). Data are represented as mean ± SD, two-tailed Student’s t-test was used to evaluate differences in all panels. Source data are provided as a Source data file.

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