Fig. 1: REV-I for 8 weeks reduces chylomicron production in HFD-challenged mice. | Nature Communications

Fig. 1: REV-I for 8 weeks reduces chylomicron production in HFD-challenged mice.

From: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1

Fig. 1

a Diagram shows experimental procedures. Body weight change (b) and body weight gain (c) of mice after 8-week treatment; n = 13 for the LFD and HFD groups and n = 14 for the HFR group. Blood glucose level and area under the curve (AUC) during OGTT (d) and IPITT (e); n = 5. Fasting blood glucose (FBG) (f) (n = 13–14 as c), fasting blood insulin (FBI) (g) (n = 5), TG (h) (n = 13–14 as c), and non-esterified FA (NEFA) levels (i) (n = 4). j Postprandial TG levels during FTT; n = 4. k, l Postprandial plasma collected 4 h after olive oil gavage was ultracentrifuged for isolating TRL (mainly chylomicron). TG concentrations were then measured (k), while ApoB48 levels were assessed by Western blotting (l); n = 4. m Heatmap summarizes metabolic effects of REV-I presented in this figure (fold change of a given parameter vs. that in HFD-fed mice which is defined as 1-fold). Statistical significance was evaluated by two-sided one-way ANOVA with Dunnett’s post hoc test (compared with HFD group). See also Supplementary Fig. 1. Data are presented as mean ± SD. Source data are provided as a Source Data file.

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