Fig. 6: The inhibitory effect of REV-I on SR-B1 involves gut microbiota.

a Diagram shows the design of the short-term FMT. Six-week-old male mice on LFD or HFD for 4 weeks were further divided randomly into three groups, receiving indicated FMT following PEG3350 treatment. b Blood glucose level and AUC during OGTT on day 7. c Basal body weight before FMT. d Body weight gain between day 0 and day 12. e Fasting TG level on day 12. f Postprandial TG level during FTT on day 12. g, h Postprandial plasma collected 4 h after olive oil gavage was ultracentrifuged to isolate TRL. TG concentrations were then measured (g), and ApoB48 levels were assessed by Western blotting (h). i Jejunal SR-B1 level. n = 4 for the LFD-HFD-FMT and HFD-HFD-FMT groups and n = 5 for the other groups in the above test. Statistical significance was evaluated by two-sided two-way ANOVA with Šidák post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001. See also Supplementary Figs. 3 and 4. Data are presented as mean ± SD. Source data are provided as a Source Data file.