Fig. 4: Hazard ratios of 26 cancer types related to age of onset of BMI ≥ 25 and ≥ 30 kg/m2 (among people who ever had a BMI ≥ 25 and ≥ 30 kg/m2, respectively) in years, respectively, with 95% CIs, allowing for non-linearity. | Nature Communications

Fig. 4: Hazard ratios of 26 cancer types related to age of onset of BMI ≥ 25 and ≥ 30 kg/m2 (among people who ever had a BMI ≥ 25 and ≥ 30 kg/m2, respectively) in years, respectively, with 95% CIs, allowing for non-linearity.

From: Longitudinal body mass index and cancer risk: a cohort study of 2.6 million Catalan adults

Fig. 4

Notes: Data are presented as HRs with the respective 95% CIs. Source data are provided as a Source Data file. Violet lines are for the age of onset of BMI ≥ 25 exposure and brown for ≥30 kg/m2. Models are adjusted for geographic region of nationality, the MEDEA deprivation index, smoking status, and alcohol intake and stratified by age (5-year categories). These graphs were obtained using restricted cubic splines with 3 knots for the exposures of interest with 40 years as the reference point (thus an HR > 1 means a greater risk at younger ages). P-values for nonlinearity were obtained by comparing the model where the exposures were fitted with a nonlinear term against a linear model using a likelihood ratio test (two-sided without adjustment for multiple comparisons). The exact p-values for duration of BMI ≥ 25 were 0.000001 (for Corpus Uteri), and for duration of BMI ≥ 30 it was 0.0001 (Corpus Uteri). Cancer types are ordered by descending ranking of the HRs for BMI at index date of Fig. 1. Models for ovary, cervix, and corpus uteri cancers were only computed in females, for breast pre-menopausal only in pre-menopausal females, for breast post-menopausal only in post-menopausal females, and for prostate and testis only computed in males. Brain and CNS includes pituitary gland and pineal gland tumors. Abbreviations: BMI Body mass index, CI confidence interval, CNS central nervous system; Lymph: Lymphoma.

Back to article page