Fig. 3: Leiomyosarcoma (LMS) is comprised of three proteomic subtypes. | Nature Communications

Fig. 3: Leiomyosarcoma (LMS) is comprised of three proteomic subtypes.

From: The proteomic landscape of soft tissue sarcomas

Fig. 3

a Annotated heatmap showing the unsupervised clustering (Spearman distance) of 3262 proteins across LMS cases (n = 80), arranged by proteomic subtype (top annotation). Bottom annotations indicate key tumour and patient characteristics, and significant (one-way ANOVA; FDR < 0.001) biological features obtained from single sample Gene Set Enrichment Analysis (ssGSEA) of the MSigDB Hallmark gene sets (Supplemental Data 6A, B). b Pie charts depicting the breakdown of LMS proteomic subtypes at different anatomical sites. c Kaplan–Meier plot of local recurrence-free survival (LRFS) across the LMS proteomic subtypes stratified by P3 and P1/P2 combined. Hazard ratio (HR), 95% confidence intervals (CI) and p-value determined by univariable Cox regression. d Multivariable Cox regression assessing local recurrence-free survival (LRFS) in patients categorised by leiomyosarcoma (LMS) proteomic subtype. I-A intra-abdominal, RP retroperitoneal.

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