Fig. 7: A summary of the roles played by the IL1R1+ CAFs in the CRC TME. The IL1R1+ subtype of CAFs is linked to lower survival and to higher tumor growth and immune evasion (M2 polarization and T cell exhaustion markers). | Nature Communications

Fig. 7: A summary of the roles played by the IL1R1+ CAFs in the CRC TME. The IL1R1+ subtype of CAFs is linked to lower survival and to higher tumor growth and immune evasion (M2 polarization and T cell exhaustion markers).

From: IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Fig. 7

IL1R1+ iCAFs show increased IL-1 signaling and NFκB pathway activation, leading to the secretion of pro-inflammatory cytokines participating in tumor growth. Finally, IL1R1+ CAFs favor infiltration of Th17 cells into the TME.

Back to article page