Fig. 3: Maternal neutralizing activity against B.1, BA.1, and BA.5 spike variants in patients with a positive history of SARS-CoV-2 infection.

a–c Neutralizing activity in patients with a positive history of SARS-CoV-2 infection stratified according to vaccination status at time of delivery: Not vaccinated with positive history of infection (NoVx/Inf); Partially vaccinated with positive history of infection (PartVx/Inf); Fully vaccinated with positive history of infection (FullVx/Inf); Boosted with positive history of infection (BoostVx/Inf). Data points are indicated as dots and plotted as boxplots (center line, median; bounds of box, the first and third quartiles; whiskers, 1.5 times interquartile range). Differences across groups were determined by two-sided Wilcoxon rank-sum test. d–f. Correlation between maternal anti-S IgG levels (log₂ transformed) and neutralizing antibody levels (log₁₀ transformed) in patients with positive history of SARS-CoV-2 infection. Not vaccinated with positive history of infection (NoVx/Inf); Partially vaccinated with positive history of infection (PartVx/Inf); Fully vaccinated with positive history of infection (FullVx/Inf); Boosted with positive history of infection (BoostVx/Inf). Spearman correlation analysis were carried out for each variant assayed: B.1; BA.1; BA.5. The half-maximal neutralization titers for each plasma (NT50). Shaded regions indicate 95% confidence intervals for each linear relationship visualized. Source data are provided as a source data file.