Fig. 1: Mechanism and overall structure of RodA-PBP2 complex.
From: Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex
a Above, schematic representation of the reaction catalyzed by RodA (green) and PBP2 (blue). Below, the chemical representation of peptidoglycan synthesis with Lipid II building blocks and chemical components of Lipid II are shown in a box on the top left. b Cryo-EM density map of the RodA-PBP2 complex. Density corresponding to RodA and PBP2 is shown in green and blue, respectively. c Structure of the RodA-PBP2 complex shown as a ribbon with RodA in green and PBP2 in blue. Approximate membrane boundaries are represented as dotted lines. d Schematic diagram showing the topology of RodA colored in rainbow from C (blue) to N terminus (red), consisting of ten TM helices and a well-ordered periplasmic region between TM helix 7 and 8. e Structure of RodA shown rotated 90°, with the ten TM helices colored as in e. Approximate membrane boundaries are again shown as dotted lines.
