Fig. 3: VOC omicron lung virus load following antiviral treatment. | Nature Communications

Fig. 3: VOC omicron lung virus load following antiviral treatment.

From: Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Fig. 3

a Schematic of the study design. Treatment with nirmatrelvir/ritonavir or molnupiravir was initiated 12 h after infection, continued b.i.d., and terminated 5 days after infection. b, c Roborovski dwarf hamster body weight (b) and temperature (c) in animals infected with VOC omicron and treated with drug or vehicle. Symbols show, and lines intersect, group means ± SD. Dotted line in (b) denotes predefined endpoint. d Infectious virus titers in lung tissue extracted on days 3 (D3; vehicle only), 5 (D5), and 9 (D9) after infection. The number of animals (n = independent animals) used in each experiment is specified. Symbols represent independent biological repeats (individual animals); columns denote geometric means ± SD. Two-way ANOVA with main effects only, Tukey’s multiple comparison post hoc test; P values are shown. Dotted line denotes limit of detection. Source data are provided as a Source data file.

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