Fig. 2: Crystal structure of the TV6.6 and human CD98hc co-complex provides molecular details of the interaction. | Nature Communications

Fig. 2: Crystal structure of the TV6.6 and human CD98hc co-complex provides molecular details of the interaction.

From: CD98hc is a target for brain delivery of biotherapeutics

Fig. 2

a Model of Fc with TV6.6 (red and blue) in complex with two copies of CD98hc (tan); PDB ID: 8G0M b Zoom in of the TV6.6 surface with engineered residues (blue sticks) and wild-type positions (gray sticks) that contact CD98hc. Surface model of CD98hc indicating residues in contact with the TV (orange) and surface exposed positions that differ between human and cynomolgus (pink). c, d Model of monovalent (c) and bivalent (d) TV binding to the CD98hc-LAT1 complex (PDB ID: 6JMQ) on the cell surface.

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