Fig. 4: Biodistribution of ATVCD98hc6.8:DNP variants in the brain is dependent on valency and FcÎłR binding in CD98hcmu/hu KI mice. | Nature Communications

Fig. 4: Biodistribution of ATVCD98hc6.8:DNP variants in the brain is dependent on valency and FcÎłR binding in CD98hcmu/hu KI mice.

From: CD98hc is a target for brain delivery of biotherapeutics

Fig. 4

a Immunohistochemical cell-specific localization of ATVCD98hc6.8:DNP variants (170 nM KD) in brain cortical sections with antibodies against huIgG (purple) and AQP4 (a, green, scale bars = 15 µm) or Iba1 (b, green, scale bars = 20 µm). Overlays are shown with colocalization pseudocolored in white. Representative image shown from n = 5/group, n = 2 stained sections per animal.

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