Fig. 4: Changes from week 18 to baseline in serum Neurofilament Light (NfL) and phosphorylated Neurofilament Heavy (pNfH) in relation to progression rate across treatment arms.
From: Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis
In detail from left to right, upper panels: changes from week 18 to baseline in serum pNfH in rapamycin (a) and placebo arm (b), in relation to progression rate calculated as the monthly decline in the ALSFRS-R from baseline to week 18. From left to right, lower panels: changes from week 18 to baseline in serum NfL in rapamycin (c) and placebo arm (d), in relation to progression rate calculated as the monthly decline in the ALSFRS-R from baseline to week 18. Individual differences in neurofilament concentration between week 18 and baseline are plotted as colored symbols (Rapamycin arms in red; placebo arm in blue). The shaded areas represent the 95% confidence intervals around the model estimates. The lines and confidence intervals are drawn from the actual distributions of linear model fits. All statistical tests were two-tailed. Source data are provided as a Source Data file.
