Fig. 1: Age-related trajectories of cognitive impairment in PSEN1 E280A mutation carriers and non-carriers. | Nature Communications

Fig. 1: Age-related trajectories of cognitive impairment in PSEN1 E280A mutation carriers and non-carriers.

From: Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease

Fig. 1

a Cross-sectional MMSE scores of PSEN1 E280A mutation carriers (red) and non-carriers (black) as a function of age. b Differences in MMSE score between PSEN1 E280A mutation carriers and non-carriers as a function of age. MMSE score declines in mutation carriers begins to differ from non-carriers at 31.5 years. The shaded areas of each plot represent the 99% credible intervals around the model estimates drawn from the distributions of model fits derived by the Hamiltonian Markov chain Monte Carlo analyses. MMSE Mini Mental State Examination. Source data are provided as a Source Data file.

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