Fig. 9: ACA PV+cal neurons show selective visual-related activity in the 2AUC change-detection task.
From: A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing
a Color-coded averaged ΔF/F (z-scored) of the contralateral-preferring PV+cal neurons in contralateral-hit (left) and ipsilateral-hit (right) trials (n = 8 mice, 8 sessions, 4 neurons). Each row shows the average activity of one neuron, sorted by peak response during the visuomotor period in the contralateral-hit trials. Black dashed line, the start of visual white noise. The left and right gray dashed lines present the start of drifting grating and the end of wheel rotation, respectively. b–d Averaged ΔF/F (z-scored) of contralateral-preferring PV+cal neurons in different types of trials. Black dashed line, the start of visual white noise. Colored shading, ± SEM. b Activity in hit trials. Gray shading, window of the visuomotor period. c Activity in miss trials. Gray shading, window during the presentation of drifting grating. d Activity in FA trials. Gray shading, window during the wheel rotation. e–h Similar to a–d, but for ipsilateral-preferring PV+cal neurons. The activity of ipsilateral-preferring PV+cal neurons was significantly lower in the contralateral-hit trials than in the ipsilateral-hit trials during the visuomotor period (P = 1.8 × 10−8, two-sided paired t-test). Similarly, the activity of ipsilateral-preferring PV+cal neurons was significantly lower in the contralateral-miss trials than in the ipsilateral-miss trials during the presentation of drifting grating (P = 0.003, two-sided paired t-test). However, there was no significant activity difference between the contralateral-FA trials and the ipsilateral-FA trials during the wheel rotation (P = 0.8, two-sided paired t-test). See also Supplementary Fig. 14 and “Methods”. Source data are provided as a Source Data file.
