Fig. 3: In vivo interactions of STPNs with GBC cells. | Nature Communications

Fig. 3: In vivo interactions of STPNs with GBC cells.

From: Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

Fig. 3

a Fluorescence images of STPNs cellular uptake by GBC-SD or EH-GB1 cells under physiological pH 7.4 and acidic tumor microenvironment pH 6.5 at different time points. DAPI-stained cells are depicted in blue; STPNs fluorescence signals are depicted in red (scale bar = 100 µm). b Cryo-TEM images of STPNs cellular uptake by GBC-SD or EH-GB1 cells at different time points. c 48 h CCK-8 assays of GBC-SD or EH-GB1 cells treated with different concentrations of TZB (equivalent to dosage in STPNs) or STPNs. d 48 h CCK-8 assays of GBC-SD or EH-GB1 cells exposed to different concentrations of SPNs or SPNs with 980 nm laser irradiation (2.0 W cm−2, 5 min with every 1 min interval). The data are represented as mean ± SD (n = 3 independent experiments, Student’s t test). *P < 0.05, **P < 0.01.

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