Fig. 5: C3N nanodots increase the expression levels of the synaptic function-related proteins in APP/PS1 mice.
From: C3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer’s disease
a SNAP25 and VAMP2 proteins levels were assessed using western blotting. b The relative expression levels of the SNAP25 and VAMP2 proteins were estimated by comparing their relative gray densities to the β-actin. n = 3 mice per group, Statistical significance was determined by unpaired Student’s t test (two-tailed) with P < 0.05 considered statistically significant. P = 0.0077 and P = 0.0075. c Quantitation of MAP2-positive neurons in cortexes. n = 18 micrographs examined over 3 independent mice. Statistical significance was determined by one-way ANOVA in with P < 0.05 considered statistically significant. P < 0.0001, P = 0.0002. d Immunohistochemistry on brain sections of different group mice. Representative micrographs of MAP2-labeled (red), SANP25-labeled (green) and DAPI (blue) in the cortex. Micrographs from three independent mice with similar results. All experiments were repeated three times. Data are presented as mean ± SD. **P < 0.01, ***P < 0.001 and ****P < 0.0001 vs APP/PS1 group Source data are provided as a Source data file.
