Fig. 10: Summary of results. | Nature Communications

Fig. 10: Summary of results.

From: Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments

Fig. 10

a Cntn1 interacts with and is redundantly recruited to the AIS through interactions with both NrCAM and Nfasc. b Loss of AIS Cntn1 (orange at AIS) from cerebellar Purkinje neurons disrupts basket cell innervation of the AIS and formation of pinceau synapses. c Loss of AIS Cntn1 (orange) from Pyramidal neurons results in reduced innervation of AIS by Chandelier cells (ChC) and reduced numbers of AIS inhibitory synapses. Created with Biorender.com.

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