Fig. 4: The most significant module (Ivory) associated with the expression of change in appetite/weight, insomnia/hypersomnia, and difficulty in concentration/indecision detected in male OFC.
From: Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
a Hubs and nodes representation of Ivory and their associations with clinical symptoms of MDD. The inner colors show to which symptom each gene (hub/node) is associated, with green for change in appetite/weight, yellow for insomnia/hypersomnia, and purple for difficulty in concentration/indecision. The surrounding color shows if the gene is differentially expressed in male (blue), female (pink) or both (purple). Hubs and nodes are defined by the size of the circles. b–d Correlation between module membership (KME) and gene significance (GS) values of the association between each gene and relevant symptomatic feature, for genes coexpressed in Ivory, in male (blue) and female (pink). Fitted linear regression lines in corresponding colors are employed to demonstrate the linear associations. The 95% confidence band (\(\overline{{GS}}\pm {t}_{0.975}{SE}_{\overline{GS}}\)) for each fitted regression line is visually indicated with a relevant, brighter color. The higher the correlation, the more relevant the module to the specific symptom. e The venn diagram shows the number of genes in Ivory module associated with at least one out of the three symptoms, with change in appetite/weight in green, insomnia/hypersomnia in yellow, and difficulty in concentration/indecision in purple. f GO enrichment for the Ivory module for the first five most significantly enriched GO terms. The black vertical line indicates the significance threshold (padj <0.05). Source data are provided as a Source Data file.
