Table 3 Univariable and Multivariable Cox Regression Analyses of Risk Factors for Survival

From: Indocyanine green fluorescence imaging-guided versus conventional laparoscopic lymphadenectomy for gastric cancer: long-term outcomes of a phase 3 randomised clinical trial

Clinicopathologic Parameters

Overall Survival

Disease-free Survival

Univariable Model

Multivariable Model

Univariable Model

Multivariable Model

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

Group

  Non-ICG

Ref

 

Ref

 

Ref

 

Ref

 

 ICG

0.50 (0.28–0.89)

0.018

0.49 (0.27-0.91)

0.023

0.53 (0.32-0.88)

0.014

0.51 (0.30-0.87)

0.014

Age, year

   ≤60

Ref

 

Ref

 

Ref

   

   >60

2.09 (1.17–3.74)

0.012

1.87 (0.99-3.52)

0.053

1.64 (1.00-2.70)

0.050

  

Sex

   Female

Ref

   

Ref

   

   Male

1.31 (0.71–2.43)

0.383

  

1.05 (0.63-1.77)

0.847

  

BMI, kg/m2

   <25

Ref

   

Ref

   

   ≥25

0.72 (0.37–1.40)

0.329

  

0.65 (0.35–1.19)

0.161

  

ECOG PS

   0

Ref

   

Ref

   

   1

1.42 (0.67–3.02)

0.360

  

1.39 (0.71–2.72)

0.338

  

Tumor ___location

   Lower

Ref

 

Ref

 

Ref

 

Ref

 

   Middle

2.23 (0.99–5.06)

0.054

1.95 (0.83-4.58)

0.125

2.34 (1.14–4.79)

0.020

1.80 (0.85-3.80)

0.124

   Upper

2.25 (1.21–4.18)

0.010

1.00 (0.52–1.93)

0.997

2.31 (1.33–4.02)

0.003

1.16 (0.65-2.06)

0.616

Histology

   Differentiated

Ref

   

Ref

   

   Undifferentiated

1.47 (0.85–2.54)

0.170

  

1.36 (0.83–2.21)

0.221

  

Lymphvascular invasion

   Negative

Ref

 

Ref

 

Ref

 

Ref

 

  Positive

3.30 (1.81–6.02)

<0.001

1.22 (0.61–2.46)

0.571

4.55 (2.59–8.00)

<0.001

1.62 (0.84-3.11)

0.147

Size, cm

   ≤3

Ref

 

Ref

 

Ref

 

Ref

 

   >3

2.69 (1.43–5.03)

0.002

1.02 (0.53–1.97)

0.954

3.81 (2.08–6.99)

<0.001

1.42 (0.75-2.67)

0.278

AJCC7th staging

   I

Ref

 

Ref

 

Ref

 

Ref

 

   II

6.62 (1.43–30.66)

0.016

12.82 (2.50–65.70)

0.002

7.44 (1.63–33.94)

0.010

15.74 (3.17-78.08)

0.001

   III

23.57 (5.70–97.50)

<0.001

40.38 (8.27–197.15)

<0.001

33.72 (8.21–138.44)

<0.001

55.07 (11.52-263.31)

<0.001

Adjuvant chemotherapy

   No

Ref

 

Ref

 

Ref

 

Ref

 

   Yes

2.11 (1.16–3.84)

0.015

0.40 (0.20–0.80)

0.009

2.50 (1.44–4.34)

0.001

0.27 (0.14-0.51)

<0.001

  1. HR hazard ratio, CI confidence interval, AJCC American Joint Committee on Cancer, BMI body mass index (calculated as weight in kilograms divided by height in meters squared), ECOG PS Eastern Cooperative Oncology performance status, ICG indocyanine green.
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