Fig. 4: Synthesis of 3, 4, or 6. | Nature Communications

Fig. 4: Synthesis of 3, 4, or 6.

From: Mechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes

Fig. 4

Reaction conditions: 1 or 5 (0.2 mmol), 2 (0.4 mmol), NaOtBu (4 equiv.), H2O (2 equiv.), [Pd(allyl)Cl]2 (2.5 mol%), Xu8 (10 mol%) in 2 mL Et2O/Hexane under N2 at RT for 72 h. Isolated yields. ee was determined by chiral HPLC analysis. b with Xu6 (10 mol%) in 2 mL toluene under N2 at RT for 72 h. c 1 (0.5 mmol), 2 (1 mmol), EtONa (4 equiv.), [Pd(allyl)Cl]2 (2.5 mol%), (R, RS)-Xu9 (10 mol%) in toluene under N2 at −20 °C for 72 h. d 5 mol% [Pd(allyl)Cl]2, 20 mol% Xu2.

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