Fig. 4: Biological processes that regulate MBEN differentiation mimic CGNP development. | Nature Communications

Fig. 4: Biological processes that regulate MBEN differentiation mimic CGNP development.

From: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

Fig. 4

a Heatmap depicting the frequencies of predicted interactions for each pair of potentially communicating cell stages amongst MBEN cells. b Dotplots depicting the most confident receptor-ligand-interactions within and between different MBEN cell stages. The interaction specificity weights indicate how specific a given interaction is to the sender and receiver cell stages. c UMAP-plot showing the expression of a Ca2+ signaling signature along MBEN differentiation (nine samples, n = 27,782 cells). To improve visibility, only cells with expression levels above the 25th quantile are highlighted. d Dotplot showing the expression of a BMP protein signature along MBEN differentiation. e Visualization of transcription factor (TF) activities within and between MBEN cell stages. Above each cell stages, the top five expressed TFs are indicated. Furthermore, the five most up- and downregulated TFs that changed during each developmental step of the MBEN trajectory are given (see also Fig. 3d). In order to design e, the image “Blue Astrocyte” (by Andrew Hardaway, licensed under https://creativecommons.org/licenses/by/4.0/) from the database https://scidraw.io/ was used. Source data are provided as a Source Data file.

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