Fig. 6: Model figure for oligodendrocyte calcium regulation of myelin sheath morphology.
From: Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension
a (left) In developing myelin sheaths, calcium regulates actin filaments, which are required to guide myelin membrane accurately around neuronal axons. (right) Loss of calcium signaling leads to myelin outfoldings and shorter myelin sheaths, and both phenotypes are recapitulated by inducing actin disassembly in oligodendrocytes. Created with Biorender.com. b Model for how different neuronal properties (e.g. caliber, activity, etc.) may regulate myelin formation or dynamics by converging on oligodendrocyte calcium signaling. Inset shows oligodendrocyte calcium signaling promoting actin dynamics that are, in turn, required for normal sheath length and morphology. Created with Biorender.com.
