Fig. 4: Causal associations between genetically determined gene expressions and TL.
From: Unraveling the causal genes and transcriptomic determinants of human telomere length
A Manhattan plot of transcriptome-wide association results. The x-axis represents the genome in physical order; the y-axis shows Z score for all genes. Genes that passed multiple testing corrections (FDR < 0.1) are highlighted in red and labeled with gene name. B–E LocusCompare plots for the (B) MMUT, (C) RRM1, (D) KIAA1429, and (E) YWHAZ loci, where the GWAS signals (x-axis) colocalized the eQTL signals (y-axis). LD is colored with respect to the GWAS lead SNPs. The lead SNPs are plotted as a purple upright triangle. The x-axis and y-axis show the -log P values for variants located at the respective loci. F–I Scatter plot of the effect sizes of variants reported in TL GWAS and placental eQTLs from (F) MMUT, (G) RRM1, (H) KIAA1429, and (I) YWHAZ. Effect sizes of the variants in the TL GWAS (y-axis) and eQTL (x-axis) are plotted. Error bars indicate 95% confidence interval. The red triangle shows the top cis-eQTL, blue circles indicate cis-eQTLs. Error bars show the standard errors of the SNP effects.
