Fig. 1: We here developed a nano-platform named KT-NE with the capability to alleviate endoplasmic reticulum stress and oxidative stress.

KT-NE was formulated with the ROS scavenger α-Tocopherol and the XBP1 hyperactivation inhibitor KIRA6. This innovative platform impeded the advancement of obesity and mitigated the associated risk of complications by restricting uncontrolled adipose hyperplasia and hypertrophy in individuals with obesity.