Fig. 3: Multi-species generalization of neuronal activity score applied to previously published chemical induction studies.
From: Using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data
Predicted activity for various neuron types responding to treatment with potent chemical modulators of neuron activity. a Response to PTZ-induced seizure (red) and controls (white) in mouse cortical neurons. b Cocaine treatment (red) or controls (white) in rat nucleus accumbens neurons. c Time series of predicted activity for human iPSCs treated with depolarizing potassium chloride at 0 h (control), 1 h, 2 h, and 4 h. Annotated statistics from Kolmogorov–Smirnov tests (one-sided) are provided in Supplementary Data 5. Boxplots depict median value, box bounds denote interquartile range (IQR), whiskers denote values within ±1.5 x IQR, and points outside of whisker range denote outliers with values ≥1.5 x IQR. Source data are provided as a Source Data file.
