Fig. 5: The BSV sensors were used to identify the β-lactamase subtypes in 100 clinical samples.
From: Rapid and visual identification of β-lactamase subtypes for precision antibiotic therapy
A The BSV testing results were verified by bacterial culture and RT-PCR. B The clinical samples involve 13 kinds of body fluids, among which the sputum samples from pneumonia patients rank the top one, reaching 56 cases. Various β-lactamase subtypes were found in these samples. C Average ± s.d. turnaround time of the BSV sensor, bacterial culture, and RT-PCR, which were compared with the AST time in the clinical data (Supplementary Data 1) (paired two-tailed Student’s t test, P < 0.0001, n = 100 biologically independent samples). Error bars: mean ± s.d. D Accuracy of β-lactamase diagnosis obtained from bacterial culture, BSV sensor, and PT-PCR. The results obtained from the BSV sensor were found to have the same clinical accuracy to the traditional culture-based β-lactamase diagnostic technique and were slightly better than those obtained from RT-PCR.
