Fig. 1: Overview of genetic landscape of Lyme disease risk factors.
From: SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
a Manhattan plot for the genome-wide association study (GWAS) of Lyme disease (LD) including 25,355 LD cases and 592,376 controls with Firth logistic regression model. All tests were two-sided. For each genetic variant, the x-axis shows chromosomal position, while y-axis shows the Bonferroni-adjusted −log10 (P) -value. The horizontal line indicates the genome-wide significance threshold of P = 5.0 × 10−8. Three genetic loci were identified at a genome-wide significance level: SCGB1D2, HLA-DQB1, and TLR1. b Locus Zoom plot shows associated Bonferroni-adjusted P values on the log10 scale on the vertical axis, and the chromosomal position along the horizontal axis. Purple diamond indicates single nucleotide polymorphism (SNP) at a locus with the strongest associated evidence. Linkage disequilibrium (LD, r2 values) between the lead SNP and the other SNPs are indicated by color. c Schematic illustration for the protein structure of SCGB1D2 where a missense variant rs2232950 is causing an amino acid substitution from proline (Pro) to leucine (Leu). The structure is alpha-helical and forms an antiparallel dimer of the two monomers. There is a cavity which can accommodate small to medium-sized ligands like steroids and phospholipids between the two dimers.
