Table 3 Homo-BacPROTACs are potent on multiple drug-resistant Mtb strains
From: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria
Compound | MIC Mtb # 11291 | MIC Mtb # 8673 | MIC Mtb ATCC 35825 | |||
|---|---|---|---|---|---|---|
|  | µM | µg/ml | µM | µg/ml | µM | µg/ml |
10 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 |
12 (UdSBI-4377) | <0.1 | <0.2 | <0.1 | <0.2 | <0.1 | <0.2 |
5 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
8 (UdSBI-0545) | <0.1 | <0.2 | <0.1 | <0.2 | <0.1 | <0.2 |
Moxifloxacin | 0.2 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
Streptomycin | 0.4 | 0.3 | 6.9 | 4.0 | 27.5 | 16.0 |
Isoniazid | 3.6 | 0.5 | 466.7 | 64.0 | 29.2 | 4.0 |
Rifampicin | 0.005 | 0.004 | 38.9 | 32.0 | 0.005 | 0.004 |
Amikacin | 3.4 | 2.0 | >218.6 | >128.0 | 0.1 | 0.03 |
Thiacetazone | 4.2 | 1.0 | >541.7 | >128.0 | 4.2 | 1.0 |
p-Aminosalicylic acid | 6.5 | 1.0 | 6.5 | 1.0 | 104.5 | 16.0 |
