Fig. 5: GRB2 depletion sensitizes cells to PARPi. | Nature Communications

Fig. 5: GRB2 depletion sensitizes cells to PARPi.

From: GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

Fig. 5

a A schematic experimental overview for monitoring cancer growth with luciferase imaging. Below, Representative images of luciferase expression ID8 cells detected on day-7 and day-28. Talazoparib (0.33 mg/kg) treated control and GRB2-KD mice are only shown. b Quantitative luciferase signal detection using IVIS imaging for n = 5 mice per group up to 28 days, the mean with ±SD are shown. c Kaplan–Myer curve showing survival of mice in the four-treatment group. d The measurements of Ascites volume n = 4 mice all 4 treatment groups, the mean with ±SD are shown. e, f Measurement of mouse IL-2 level and IL-12 in the Ascites fluids of n = 4 mice, the mean with ±SD are shown. The significance was analyzed by two-sided Student’s t test. *P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001; NS not significant. For (b–f), source data are provided as a Source Data file.

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