Fig. 7: Polyamine promotes radiotherapy- and chemotherapy-induced ferroptosis.
From: Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer
a Clonogenic survival curves of A549 or HT1080 cells exposed to radiotherapy (RT) at indicated doses following pre-treatment with polyamines. b Cell viability in A549 or HT1080 cells treated with CDDP as indicated for 48 h following pre-treatment with polyamines. c Lipid peroxidation assessment in A549 or HT1080 cells at 24 h after exposure to 6 Gy of RT or 10 μM CDDP following pre-treatment with polyamines. d (left) Clonogenic survival fraction of A549 or HT1080 cells exposed to radiotherapy (RT) at indicated doses combined with or without Fer-1 following pre-treatment with polyamines. (right) Cell viability in A549 or HT1080 cells treated with CDDP (A549: 20 μM; HT1080: 10 μM) combined with or without Fer-1 for 48 h following pre-treatment with polyamines. Data are presented as the mean ± SD, n = 3 independent experiments. Unpaired two-tailed Student’s t tests are used. Source data are provided as a Source Data file.
