Fig. 8: Polyamine metabolism is a potential target of ferroptosis-based cancer treatment.
From: Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer
a–d Image of resected tumours from A549 mice xenografts. Groups of mice were treated as indicated (n = 6 per group). The growth of tumour volumes and the final weight of resected tumours were also shown (a, c). Representative immunohistochemical images of the resected tumours in each group (scale bars, 40 μm) (b, d). e The distribution of polyamines in the section of the surgically resected LUAD and adjacent normal tissue, determined by spatially resolved metabolomics. f A schematic model depicting the polyamine-mediated ferroptosis amplification and diffusion. Panel f is generated using Biorender. Data are presented as the mean ± SD. Unpaired two-tailed Student’s t tests are used. Source data are provided as a Source Data file.
