Fig. 8: Proposed model of TP63-suppressed immune response in squamous cancer. | Nature Communications

Fig. 8: Proposed model of TP63-suppressed immune response in squamous cancer.

From: Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer

Fig. 8

Squamous cell master regulator TP63 represses the IFNγ signaling through antagonizing STAT1 in occupying the regulatory elements of themselves. The relative expression between STAT1 and TP63 dictates the strength of IFNγ signaling, which determines immune response by regulating CD8+ T cell activity. Inhibition of TP63 improves anti-tumor effect of PD-1 mAb therapy. The Figure was created with BioRender.com.

Back to article page