Fig. 7: Predicted cell and tissue microstructure proportions across 30 whole slide images (WSI) of healthy term placentas and 12 WSIs of placentas with placental infarction.

a Cell proportions across healthy term placentas, b cell proportions across term placentas with placental infarction, c tissue proportions across healthy term placentas, d tissue proportions across term placentas with placental infarction. Box centre line represents the median and whiskers are drawn up to 1.5 times the interquartile range. Each WSI datapoint is shown by a cross marker. Expected healthy ranges for tissue microstructures, as reported in the literature, are shown by black vertical bars. Nominal significant differences in cell and tissue structures between the two groups are calculated using two-sided Welch’s t-test and shown by red asterisks. Statistically significant cell proportion differences are seen for syncytiotrophoblasts (p = 0.001), fibroblasts (p = 0.002), vascular endothelial cells (p < 0.001), extravillus trophoblasts (p = 0.001), leucocytes (p = 0.002), mesenchymal cells (p = 0.02) and maternal decidual cells (p = 0.04). Statistically significant tissue proportion differences are seen for terminal villi (p < 0.001), mature intermediate villi (p = 0.03), villus sprouts (p = 0.01), anchoring villi (p = 0.02), basal plate/septum (p = 0.02), fibrin (p = 0.002) and avascular villi (p = 0.001). Source data are provided as a Source Data file.