Fig. 3: DSB distribution at the corresponding “unidirectional” and biphasic-replicating RDCs. | Nature Communications

Fig. 3: DSB distribution at the corresponding “unidirectional” and biphasic-replicating RDCs.

From: Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters

Fig. 3

A Left panel: illustration of a unidirectional rightward-moving fork. The figure is organized as shown in Fig. 2B. Right panel: multiomics data provide information regarding the Large locus containing a “unidirectional” RDC in aphidicolin-treated ES cell-derived NPCs. TTR: timing transition region. B Left panel: illustration of a unidirectional leftward-moving fork. Right panel: multiomics plot showing the replication, RDC break distribution, and associated annotations at Csmd2 locus in ES cell-derived NPCs treated with APH. C Multiomics panels show the Samd5 and Rora loci information containing biphasic “inward-moving” RDC. D Multiomics panels show the information of the Auts2 and Tenm4 gene loci, which contain biphasic “complex” RDC. The multiomics panels are shown as described in Fig. 2C. E A panel summarizes RDC types based on DNA replication direction, with the plot indicating the count for each type. Biphasic RDC is a distinctive feature; it does not constitute a separate category. CTR constant timing region.

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