Fig. 6: CoH-catalyzed Markovnikov hydroalkylation. | Nature Communications

Fig. 6: CoH-catalyzed Markovnikov hydroalkylation.

From: Enantioselective synthesis of chiral α,α-dialkyl indoles and related azoles by cobalt-catalyzed hydroalkylation and regioselectivity switch

Fig. 6

Condition B: aAll reaction were carried out with 1’ (0.10 mmol), 2 (0.20 mmol, 2.0 equiv), CoI2 (10 mol%), L12 (12 mol%), CsF (0.20 mmol, 2.0 equiv), DEMS (0.20 mmol, 2.0 equiv), THF (0.5 mL, 0.2 M), 40 oC, 24 h. Isolated yields. The regioisomeric ratio (rr) > 20:1 in all cases. bPh2SiH2 instead of DEMS. cCoBr2·DME instead of CoI2.

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