Fig. 2: SOX13 dependence in ferroptosis-resistant GC. | Nature Communications

Fig. 2: SOX13 dependence in ferroptosis-resistant GC.

From: Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer

Fig. 2

A, B Effect of SOX13 downregulation and SOX13 re-expression on Erastin (2 μM) or RSL3 (0.5 μM) sensitivity in the absence or presence of Fer-1 (1 μM) in resistant cells. The cells were treated with FINs for 24 h. A Intracellular MDA was assayed with ELISA (n = 3 independent experiments). Data are presented as mean values ± SD. B Lipid peroxidation was determined with a lipid peroxidation C11-BODIPY assay in SNU-668 Erastinresis cells (n = 3 independent experiments), and a representative flow cytometry histogram plot is presented. Data are presented as mean values ± SD. Statistical significance in (A) and (B) is determined by two-tailed unpaired t test. Source data are provided as a Source Data file.

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